On one side is Harvard, the nation's oldest and wealthiest university, with a brand so powerful that its name is synonymous with prestige. On the other side is the Trump administration, determined to go further than any other White House to reshape American higher education.
Both sides are digging in for a clash that could test the limits of the government's power and the independence that has made U.S. universities a destination for scholars around the world.
On Monday, Harvard became the first university to openly defy the Trump administration as it demands sweeping changes to limit activism on campus. The university frames the government's demands as a threat not only to the Ivy League school but to the autonomy that the Supreme Court has long granted American universities.
''The university will not surrender its independence or relinquish its constitutional rights,'' the university's lawyers wrote Monday to the government. ''Neither Harvard nor any other private university can allow itself to be taken over by the federal government.''
The federal government says it's freezing more than $2.2 billion in grants and $60 million in contracts to Harvard. The hold on funding marks the seventh time the Trump administration has taken such a step at one of the nation's most elite colleges, in an attempt to force compliance with Trump's political agenda. Six of the seven schools are in the Ivy League.
Harvard is uniquely equipped to push back
No university is better positioned to put up a fight than Harvard, whose $53 billion endowment is the largest in the nation. But like other major universities, Harvard also depends on the federal funding that fuels its scientific and medical research. It's unclear how long Harvard could continue without the frozen money.
Already, Harvard's refusal appears to be emboldening other institutions.